Epigenetic modulation and apoptotic induction by a novel imidazo-benzamide derivative in human lung adenocarcinoma cells | Zendy

Amrutha Arjunan | Zendy; P. Sankar | Zendy; Arul Prakash Francis | Zendy; Srividya Subramanian | Zendy; Sathyapriya Chandramohan | Zendy; D. Parthasarathi | Zendy; Ayyiliath M. Sajith | Zendy; M. Syed Ali Padusha | Zendy; Premendu P. Mathur | Zendy; Rukkumani Rajagopalan | Zendy

Open Access

Epigenetic modulation and apoptotic induction by a novel imidazo-benzamide derivative in human lung adenocarcinoma cells

Author(s) -

Amrutha Arjunan,

P. Sankar,

Arul Prakash Francis,

Srividya Subramanian,

Sathyapriya Chandramohan,

D. Parthasarathi,

Ayyiliath M. Sajith,

M. Syed Ali Padusha,

Premendu P. Mathur,

Rukkumani Rajagopalan

Publication year - 2021

Publication title -

daru journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.645

H-Index - 42

eISSN - 2008-2231

pISSN - 1560-8115

DOI - 10.1007/s40199-021-00419-3

Subject(s) - benzamide , epigenetics , apoptosis , chemistry , cancer research , histone deacetylase , dna fragmentation , cancer cell , lung cancer , a549 cell , microbiology and biotechnology , histone deacetylase inhibitor , cancer , biology , programmed cell death , biochemistry , histone , dna , medicine , gene , genetics , pathology , organic chemistry

Lung cancer is the most commonly diagnosed and leading cause of cancer death worldwide. Imidazo-benzamides are considered to be good anti-cancer agents. The present study was aimed to investigate the cytotoxicity of a novel imidazo-benzamide derivative N-(2-(3-(tert-butyl)ureido)ethyl)-4-(1H-imidazol-1-yl)benzamide (TBUEIB) in lung cancer cell line A549.

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