Open AccessEpigenetic modulation and apoptotic induction by a novel imidazo-benzamide derivative in human lung adenocarcinoma cells
Author(s) -
Amrutha Arjunan,
Sankar Pajaniradje,
Arul Prakash Francis,
Srividya Subramanian,
Sathyapriya Chandramohan,
D. Parthasarathi,
Ayyiliath M. Sajith,
M. Syed Ali Padusha,
P. B. Mathur,
Rukkumani Rajagopalan
Publication year - 2021
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-021-00419-3
Subject(s) - benzamide , epigenetics , apoptosis , chemistry , cancer research , histone deacetylase , dna fragmentation , cancer cell , lung cancer , a549 cell , microbiology and biotechnology , histone deacetylase inhibitor , cancer , biology , programmed cell death , biochemistry , histone , dna , medicine , gene , genetics , pathology , organic chemistry
Lung cancer is the most commonly diagnosed and leading cause of cancer death worldwide. Imidazo-benzamides are considered to be good anti-cancer agents. The present study was aimed to investigate the cytotoxicity of a novel imidazo-benzamide derivative N-(2-(3-(tert-butyl)ureido)ethyl)-4-(1H-imidazol-1-yl)benzamide (TBUEIB) in lung cancer cell line A549.