Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis | Zendy

Syed Ali Raza Shah | Zendy; M. Israr Khan | Zendy; Hira Jawaid | Zendy; Urooj Qureshi | Zendy; Zaheer UlHaq | Zendy; M. Rahman Hafizur | Zendy

Open Access

Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis

Author(s) -

Syed Ali Raza Shah,

M. Israr Khan,

Hira Jawaid,

Urooj Qureshi,

Zaheer UlHaq,

M. Rahman Hafizur

Publication year - 2021

Publication title -

daru journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.645

H-Index - 42

eISSN - 2008-2231

pISSN - 1560-8115

DOI - 10.1007/s40199-021-00412-w

Subject(s) - nicotinamide , apoptosis , cinnamic acid , secretion , insulin , signal transduction , chemistry , microbiology and biotechnology , cancer research , medicine , endocrinology , biology , biochemistry , enzyme

Pancreatic β-cells protection is integral to insulin secretion in diabetic conditions. In this context, we investigated cinnamic acid in combination with nicotinamide on the regulation of insulin secretion and apoptosis in pancreatic β-cells using streptozotocin (STZ)-induced apoptotic model in vivo.

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