Open AccessNicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis
Author(s) -
Syed Muhammad Mukarram Shah,
Majid Khan,
Hira Jawaid,
Urooj Qureshi,
Zaheer Ul-Haq,
M. Rahman Hafizur
Publication year - 2021
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-021-00412-w
Subject(s) - nicotinamide , insulin , medicine , apoptosis , pancreatic islets , endocrinology , mapk/erk pathway , chemistry , streptozotocin , in vivo , biology , diabetes mellitus , signal transduction , islet , biochemistry , microbiology and biotechnology , enzyme
Pancreatic β-cells protection is integral to insulin secretion in diabetic conditions. In this context, we investigated cinnamic acid in combination with nicotinamide on the regulation of insulin secretion and apoptosis in pancreatic β-cells using streptozotocin (STZ)-induced apoptotic model in vivo.