Open AccessAn Insilico evaluation of phytocompounds from Albizia amara and Phyla nodiflora as cyclooxygenase-2 enzyme inhibitors
Author(s) -
Yukeswaran Loganathan,
Manav Jain,
Subhashini Thiyagarajan,
Shreeranjana Shanmuganathan,
Suresh Kumar Mariappan,
Moni Philip Jacob Kizhakedathil,
Tamilselvi Saravanakumar
Publication year - 2021
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-021-00408-6
Subject(s) - cyclooxygenase , traditional medicine , enzyme , biology , chemistry , medicine , biochemistry
The enzyme Cyclooxygenases (COX-1 and COX-2) catalyze the formation of prostaglandin, a mediator of the inflammatory pathway. Inflammation related pathological conditions may be alleviated by targeting the Cox enzymes.COX-2 inhibitors that are currently available in the market causes undesirable side effects. Our present study focuses on the in-silico inhibition of COX -2 enzyme by the phytocompounds from Albizia amara and Phyla nodiflora.