Open AccessTumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition
Author(s) -
Maryam Sadat Hosseini,
Kaveh Baghaei,
Davar Amani,
Massoumeh Ebtekar
Publication year - 2021
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-021-00400-0
Subject(s) - microvesicles , apoptosis , cancer research , microrna , viability assay , tumor progression , in vitro , gene silencing , cancer , medicine , chemistry , biology , gene , biochemistry
MicroRNA (miR)-34a, as a master tumor suppressor in colorectal cancer (CRC), could regulate multiple genes participating in tumor proliferation, invasion, immune evasion, and inflammation-induced progression. Exosomes, as novel nano-carriers, were found to be capable of shuttling crucial mediators to various cells. Since the conventional CRC therapeutics currently are a matter of debate, implication of microRNAs in malignancy remedies have been addressed illustrating promising outlooks.