Tumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition | Zendy

Maryam Hosseini | Zendy; Kaveh Baghaei | Zendy; Davar Amani | Zendy; Massoumeh Ebtekar | Zendy

Open Access

Tumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition

Author(s) -

Maryam Hosseini,

Kaveh Baghaei,

Davar Amani,

Massoumeh Ebtekar

Publication year - 2021

Publication title -

daru journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.645

H-Index - 42

eISSN - 2008-2231

pISSN - 1560-8115

DOI - 10.1007/s40199-021-00400-0

Subject(s) - microvesicles , apoptosis , cancer research , microrna , viability assay , tumor progression , in vitro , gene silencing , cancer , medicine , chemistry , biology , gene , biochemistry

MicroRNA (miR)-34a, as a master tumor suppressor in colorectal cancer (CRC), could regulate multiple genes participating in tumor proliferation, invasion, immune evasion, and inflammation-induced progression. Exosomes, as novel nano-carriers, were found to be capable of shuttling crucial mediators to various cells. Since the conventional CRC therapeutics currently are a matter of debate, implication of microRNAs in malignancy remedies have been addressed illustrating promising outlooks.

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