Molecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection | Zendy

Muhammad Hassan | Zendy; Atif Amin Baig | Zendy; Syed Awais Attique | Zendy; Shafqat Abbas | Zendy; Fizza Khan | Zendy; Sara Zahid | Zendy; Quratul Ain | Zendy; Muhammad Usman | Zendy; Nordin Simbak | Zendy; Mohammad Amjad Kamal | Zendy; Hanani Ahmad Yusof | Zendy

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Molecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection

Author(s) -

Muhammad Hassan,

Atif Amin Baig,

Syed Awais Attique,

Shafqat Abbas,

Fizza Khan,

Sara Zahid,

Quratul Ain,

Muhammad Usman,

Nordin Simbak,

Mohammad Amjad Kamal,

Hanani Ahmad Yusof

Publication year - 2021

Publication title -

daru journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.645

H-Index - 42

eISSN - 2008-2231

pISSN - 1560-8115

DOI - 10.1007/s40199-020-00384-3

Subject(s) - enolase , streptococcus pneumoniae , docking (animal) , in silico , chemistry , biology , pharmacology , biochemistry , medicine , immunology , gene , antibiotics , immunohistochemistry , nursing

To predict potential inhibitors of alpha-enolase to reduce plasminogen binding of Streptococcus pneumoniae (S. pneumoniae) that may lead as an orally active drug. S. pneumoniae remains dominant in causing invasive diseases. Fibrinolytic pathway is a critical factor of S. pneumoniae to invade and progression of disease in the host body. Besides the low mass on the cell surface, alpha-enolase possesses significant plasminogen binding among all exposed proteins.

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