Open AccessMolecular docking of alpha-enolase to elucidate the promising candidates against Streptococcus pneumoniae infection
Author(s) -
Muhammad Nadeem Hassan,
Atif Amin Baig,
Syed Awais Attique,
Shafqat Abbas,
Fizza Khan,
Sara Zahid,
Qurat Ul Ain,
Muhammad Usman,
Nordin Simbak,
Mohammad Amjad Kamal,
Hanani Ahmad Yusof
Publication year - 2021
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-020-00384-3
Subject(s) - enolase , streptococcus pneumoniae , docking (animal) , in silico , chemistry , biology , pharmacology , biochemistry , medicine , immunology , gene , antibiotics , immunohistochemistry , nursing
To predict potential inhibitors of alpha-enolase to reduce plasminogen binding of Streptococcus pneumoniae (S. pneumoniae) that may lead as an orally active drug. S. pneumoniae remains dominant in causing invasive diseases. Fibrinolytic pathway is a critical factor of S. pneumoniae to invade and progression of disease in the host body. Besides the low mass on the cell surface, alpha-enolase possesses significant plasminogen binding among all exposed proteins.