Open AccessFunctional network analysis reveals potential repurposing of β-blocker atenolol for pancreatic cancer therapy
Author(s) -
Adam Hermawan,
Herwandhani Putri,
Rohmad Yudi Utomo
Publication year - 2020
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-020-00375-4
Subject(s) - pancreatic cancer , atenolol , mmp9 , medicine , bioinformatics , cancer research , cancer , pharmacology , biology , gene , downregulation and upregulation , blood pressure , biochemistry
The survival rate of patients with pancreatic cancer is low; therefore, continuous discovery and development of novel pancreatic cancer drugs are required. Functional network analysis is an integrated bioinformatics approach based on gene, target, and disease networks interaction, and it is extensively used in drug discovery and development.