Development, optimization and in vitro evaluation of oxaliplatin loaded nanoparticles in non-small cell lung cancer | Zendy

Özgür Eşi̇m | Zendy; Nurgül K. Bakırhan | Zendy; Nuray Yıldırım | Zendy; Meral Sarper | Zendy; Ayhan Savaşer | Zendy; Síbel A. Özkan | Zendy; Yalçın Özkan | Zendy

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Development, optimization and in vitro evaluation of oxaliplatin loaded nanoparticles in non-small cell lung cancer

Author(s) -

Özgür Eşi̇m,

Nurgül K. Bakırhan,

Nuray Yıldırım,

Meral Sarper,

Ayhan Savaşer,

Síbel A. Özkan,

Yalçın Özkan

Publication year - 2020

Publication title -

daru journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.645

H-Index - 42

eISSN - 2008-2231

pISSN - 1560-8115

DOI - 10.1007/s40199-020-00374-5

Subject(s) - oxaliplatin , bioavailability , nanoparticle , factorial experiment , zeta potential , dispersity , polycaprolactone , particle size , nanocarriers , cytotoxicity , chemistry , pulmonary surfactant , materials science , pharmacology , in vitro , nanotechnology , cancer , colorectal cancer , medicine , biochemistry , organic chemistry , mathematics , polymer , statistics

Platinum-based chemotherapy in non-small cell lung cancer (NSCLC) has been demonstrated as a promising approach by many researchers. However, due to low bioavailability and several side effects, drug targeting to lungs by intravenous administration is not a common route of administration.

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