Open AccessDevelopment, optimization and in vitro evaluation of oxaliplatin loaded nanoparticles in non-small cell lung cancer
Author(s) -
Özgür Eşi̇m,
Nurgul K. Bakırhan,
Nuray Yıldırım,
Meral Sarper,
Ayhan Savaşer,
Síbel A. Özkan,
Yalçın Özkan
Publication year - 2020
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-020-00374-5
Subject(s) - oxaliplatin , bioavailability , nanoparticle , factorial experiment , zeta potential , dispersity , polycaprolactone , particle size , nanocarriers , cytotoxicity , chemistry , pulmonary surfactant , materials science , pharmacology , in vitro , nanotechnology , cancer , colorectal cancer , medicine , biochemistry , organic chemistry , mathematics , polymer , statistics
Platinum-based chemotherapy in non-small cell lung cancer (NSCLC) has been demonstrated as a promising approach by many researchers. However, due to low bioavailability and several side effects, drug targeting to lungs by intravenous administration is not a common route of administration.