Open AccessSynthesis and evaluation of in vitro cytotoxic effects of triazol/spiroindolinequinazolinedione, triazol/indolin-3-thiosemicarbazone and triazol/thiazol-indolin-2-one conjugates
Author(s) -
Saeed Nazari,
Fatemeh Safari,
Mohammad Barasm Mamaghani,
Ayoob Bazgir
Publication year - 2020
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-020-00364-7
Subject(s) - cytotoxic t cell , clonogenic assay , chemistry , apoptosis , in vitro , lncap , cancer cell , oxindole , dapi , cancer research , cancer , pharmacology , biology , biochemistry , catalysis , genetics
Cancer as one of the major diseases with high mortality rates threats human life in the world. Subsequently, the design new potent anticancer agents has attracted much attention in the area of synthetic and medicinal chemistry. In this study, new triazol-linked spiroindolinequinazolinone, thiazol-oxindole and oxindole-thiosemicarbazone conjugates were synthesized and evaluated for their in vitro cytotoxic activity toward different cancer lines.