Open AccessEvaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin
Author(s) -
Navid Neyshaburinezhad,
Maryam Seidabadi,
Mohammad-Reza Rouini,
Hoda Lavasani,
Alireza Foroumadi,
Yalda H. Ardakani
Publication year - 2020
Publication title -
daru
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 42
eISSN - 2008-2231
pISSN - 1560-8115
DOI - 10.1007/s40199-020-00350-z
Subject(s) - dextromethorphan , metformin , medicine , endocrinology , insulin , type 2 diabetes , diabetes mellitus , enzyme , chemistry , pharmacology , biochemistry
Conversion in the metabolism of drugs occurs in diabetes mellitus. Considering the importance of metabolic enzymes' activities on the efficacy and safety of medicines, the changes in liver enzymatic activity of CYP2D1 and its related hepatic clearance, by using Dextromethorphan as probe in the animal model of type I and type II diabetes, before and after treatment, was assessed in this study.