Kartogenin Promotes the BMSCs Chondrogenic Differentiation in Osteoarthritis by Down-Regulation of miR-145-5p Targeting Smad4 Pathway | Zendy

Huimin Liu | Zendy; Ping Liu | Zendy

Open Access

Kartogenin Promotes the BMSCs Chondrogenic Differentiation in Osteoarthritis by Down-Regulation of miR-145-5p Targeting Smad4 Pathway

Author(s) -

Huimin Liu,

Ping Liu

Publication year - 2021

Publication title -

tissue engineering and regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 23

eISSN - 2212-5469

pISSN - 1738-2696

DOI - 10.1007/s13770-021-00390-9

Subject(s) - chondrogenesis , mesenchymal stem cell , aggrecan , osteoarthritis , chemistry , cartilage , stat3 , in vivo , microbiology and biotechnology , microrna , medicine , signal transduction , anatomy , pathology , biology , articular cartilage , biochemistry , alternative medicine , gene

Transplantation of mesenchymal stem cells (MSCs) is a potential therapeutic strategy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic differentiation of the implanted MSCs in the joints remains a challenge. The role of kartogenin (KGN) for chondrogenesis of MSCs has been widely reported, however, the mechanism of chondrogenesis has not been elucidated in OA.

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