Open AccessKartogenin Promotes the BMSCs Chondrogenic Differentiation in Osteoarthritis by Down-Regulation of miR-145-5p Targeting Smad4 Pathway
Author(s) -
Huimin Liu,
Ping Liu
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00390-9
Subject(s) - chondrogenesis , mesenchymal stem cell , aggrecan , osteoarthritis , chemistry , cartilage , stat3 , in vivo , microbiology and biotechnology , microrna , medicine , signal transduction , anatomy , pathology , biology , articular cartilage , biochemistry , alternative medicine , gene
Transplantation of mesenchymal stem cells (MSCs) is a potential therapeutic strategy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic differentiation of the implanted MSCs in the joints remains a challenge. The role of kartogenin (KGN) for chondrogenesis of MSCs has been widely reported, however, the mechanism of chondrogenesis has not been elucidated in OA.