Open AccessRole of Free Catecholamine in Thiol-Ene Crosslinking for Hyaluronic Acid Hydrogels with High Loading Efficiency of Anticancer Drugs
Author(s) -
Sumin Kim,
Mikyung Shin
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00388-3
Subject(s) - self healing hydrogels , dopamine , biocompatibility , hyaluronic acid , chemistry , comonomer , chemical engineering , polymer chemistry , polymerization , polymer , materials science , organic chemistry , genetics , neuroscience , engineering , biology
Hyaluronic acid (HA) is a widely used polysaccharide in biomedical field because of its excellent biocompatibility. Its chemical structure can be modified with various functional groups. Recently, dopamine has been tethered onto the polymeric backbone to ensure long-term stability and tissue adhesiveness of HA hydrogel. However, the radical scavenging effect of dopamine on typical photo-induced crosslinking for hydrogels has not been specifically studied.