Open AccessSynergistic Promoting Effects of X-Linked Inhibitor of Apoptosis Protein and Matrix on the In Vitro Follicular Maturation of Marmoset Follicles
Author(s) -
Yoon Young Kim,
Jun-Won Yun,
Sung Woo Kim,
Hoon Kim,
ByeongCheol Kang,
SeungYup Ku
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00387-4
Subject(s) - marmoset , xiap , biology , folliculogenesis , follicular phase , ovarian follicle , in vitro maturation , paracrine signalling , endocrinology , medicine , follicle , oocyte , andrology , apoptosis , microbiology and biotechnology , receptor , embryo , programmed cell death , caspase , paleontology , biochemistry , cryopreservation
In vitro follicular maturation (IVFM) of ovarian follicles is an emerging option for fertility preservation. Many paracrine factors and two-dimensional or three-dimensional (3D) environments have been used for optimization. However, since most studies were conducted using the murine model, the physiological differences between mice and humans limit the interpretation and adaptation of the results. Marmoset monkey is a non-human primate (NHPs) with more similar reproductive physiology to humans. In this study, we attempted to establish a 3D matrix (Matrtigel)-based IVFM condition for marmoset ovarian follicles in combination with anti-apoptotic factor, X-linked inhibitor of apoptosis protein (XIAP).