Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis | Zendy

Qing Wang | Zendy; Yong Chen | Zendy; Xiaofeng Shen | Zendy; Ji Chen | Zendy; Yuwei Li | Zendy

Open Access

Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis

Author(s) -

Qing Wang,

Yong Chen,

Xiaofeng Shen,

Ji Chen,

Yuwei Li

Publication year - 2021

Publication title -

tissue engineering and regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 23

eISSN - 2212-5469

pISSN - 1738-2696

DOI - 10.1007/s13770-021-00384-7

Subject(s) - aggrecan , osteoarthritis , mesenchymal stem cell , chondrogenesis , cartilage , transfection , medicine , stem cell , chemistry , pharmacology , articular cartilage , microbiology and biotechnology , pathology , anatomy , biology , biochemistry , alternative medicine , gene

Stem cells intra-articular injection stagey indicated a potential therapeutic effect on improving the pathological progress of osteoarthritis (OA). However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear. miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA.

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