Open AccessIntra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis
Author(s) -
Qing Wang,
Yong Chen,
Xiaofeng Shen,
Ji Chen,
Yuwei Li
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00384-7
Subject(s) - aggrecan , osteoarthritis , mesenchymal stem cell , chondrogenesis , cartilage , transfection , medicine , stem cell , chemistry , pharmacology , articular cartilage , microbiology and biotechnology , pathology , anatomy , biology , biochemistry , alternative medicine , gene
Stem cells intra-articular injection stagey indicated a potential therapeutic effect on improving the pathological progress of osteoarthritis (OA). However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear. miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA.