A Freezing and Thawing Method for Fabrication of Small Gelatin Nanoparticles with Stable Size Distributions for Biomedical Applications

Gelatin, a natural polymer, has a number of advantages as a material for fabricating nanoparticles, such as its hydrophilicity, biodegradability, nontoxicity, and biocompatibility, as well as low cost. Despite these various advantages, gelatin-based nanoparticles still have critical limitation for biomedical applications due to their relatively larger size than those of other materials.