Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering | Zendy

Ya Hui Tang | Zendy; Jialiang Tian | Zendy; Long Li | Zendy; Lin Huang | Zendy; Quan Shen | Zendy; Shanzhu Guo | Zendy; Yue Jiang | Zendy

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Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering

Author(s) -

Ya Hui Tang,

Jialiang Tian,

Long Li,

Lin Huang,

Quan Shen,

Shanzhu Guo,

Yue Jiang

Publication year - 2021

Publication title -

tissue engineering and regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 23

eISSN - 2212-5469

pISSN - 1738-2696

DOI - 10.1007/s13770-021-00376-7

Subject(s) - scaffold , tissue engineering , anterior cruciate ligament , biomedical engineering , ligament , materials science , anatomy , engineering , medicine

Replacing damaged anterior cruciate ligaments (ACLs) with tissue-engineered artificial ligaments is challenging because ligament scaffolds must have a multiregional structure that can guide stem cell differentiation. Here, we designed a biphasic scaffold and evaluated its effect on human marrow mesenchymal stem cells (MSCs) under dynamic culture conditions as well as rat ACL reconstruction model in vivo.

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