Open AccessBiomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering
Author(s) -
Ya Hui Tang,
Jialiang Tian,
Long Li,
Lin Huang,
Quan Shen,
Shanzhu Guo,
Yue Jiang
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00376-7
Subject(s) - scaffold , tissue engineering , plga , biomedical engineering , mesenchymal stem cell , anterior cruciate ligament , materials science , ligament , in vivo , fibroblast , chemistry , microbiology and biotechnology , anatomy , in vitro , nanotechnology , biology , medicine , biochemistry , nanoparticle
Replacing damaged anterior cruciate ligaments (ACLs) with tissue-engineered artificial ligaments is challenging because ligament scaffolds must have a multiregional structure that can guide stem cell differentiation. Here, we designed a biphasic scaffold and evaluated its effect on human marrow mesenchymal stem cells (MSCs) under dynamic culture conditions as well as rat ACL reconstruction model in vivo.