Effect of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells on Bisphosphonate-Related Osteonecrosis of the Jaw | Zendy

Gwanghyun Yang | Zendy; YoungNam Kim | Zendy; HyunJeong Kim | Zendy; BuKyu Lee | Zendy

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Effect of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells on Bisphosphonate-Related Osteonecrosis of the Jaw

Author(s) -

Gwanghyun Yang,

YoungNam Kim,

HyunJeong Kim,

BuKyu Lee

Publication year - 2021

Publication title -

tissue engineering and regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 23

eISSN - 2212-5469

pISSN - 1738-2696

DOI - 10.1007/s13770-021-00372-x

Subject(s) - mesenchymal stem cell , medicine , osteonecrosis of the jaw , bisphosphonate , umbilical cord , cancer research , proinflammatory cytokine , bone marrow , pathology , inflammation , immunology , osteoporosis

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe sequela caused by bisphosphonates (BPs), which are widely used to treat osteoporosis or other malignancies. However, the mechanism underlying BRONJ remains unclear. Recently, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been studied for treatment of diverse diseases and injuries. This study aimed to investigate the therapeutic effects of hUC-MSCs in BRONJ.

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