Open AccessEffect of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells on Bisphosphonate-Related Osteonecrosis of the Jaw
Author(s) -
Geunhyeok Yang,
Young Nam Kim,
Hyun-Jeong Kim,
Bu-Kyu Lee
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00372-x
Subject(s) - mesenchymal stem cell , medicine , osteonecrosis of the jaw , bisphosphonate , umbilical cord , cancer research , proinflammatory cytokine , bone marrow , pathology , inflammation , immunology , osteoporosis
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe sequela caused by bisphosphonates (BPs), which are widely used to treat osteoporosis or other malignancies. However, the mechanism underlying BRONJ remains unclear. Recently, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been studied for treatment of diverse diseases and injuries. This study aimed to investigate the therapeutic effects of hUC-MSCs in BRONJ.