Open AccessThe Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
Author(s) -
Seokhyeong Go,
Mikyung Kang,
Sung Pil Kwon,
Mungyo Jung,
Ok Hee Jeon,
Byung Soo Kim
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00346-z
Subject(s) - senescence , apoptosis , microbiology and biotechnology , cell , bleomycin , cancer research , programmed cell death , in vitro , annexin a5 , viability assay , biology , chemistry , biochemistry , chemotherapy , genetics
Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis.