Open AccessTGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13
Author(s) -
Jae Young Park,
Hyun Cheol Bae,
Sung Hee Pyo,
Myung Chul Lee,
Hyuck Han
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-021-00342-3
Subject(s) - chondrocyte , cartilage , osteoarthritis , transforming growth factor , tissue transglutaminase , catabolism , type ii collagen , chemistry , matrix metalloproteinase , immunostaining , microbiology and biotechnology , endocrinology , medicine , pathology , biology , anatomy , biochemistry , immunohistochemistry , enzyme , alternative medicine , metabolism
Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in chondrocyte catabolism remains unclear. Thus, we examined whether TGFβ1 increases catabolic processes in the osteoarthritic joint via transglutaminase 2 (TG2). In this study, we investigated whether interplay between TGFβ1 and TG2 mediates chondrocyte catabolism and cartilage degeneration in osteoarthritis.