Open AccessMesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts
Author(s) -
Soon Jin Choi,
Suk Young Park,
Y. H. Shin,
SeungHo Heo,
Kang-Hyun Kim,
Hyoin Lee,
Jae Kwang Kim
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00329-6
Subject(s) - neurotrophic factors , neurite , mesenchymal stem cell , regeneration (biology) , sciatic nerve , wharton's jelly , microbiology and biotechnology , peripheral nerve injury , schwann cell , biology , neuroscience , glial cell line derived neurotrophic factor , nerve guidance conduit , stem cell , pathology , anatomy , medicine , in vitro , biochemistry , receptor
Schwann cells (SCs) secrete neurotrophic factors and provide structural support and guidance during axonal regeneration. However, nearby nerves may be damaged to obtain primary SCs, and there is a lack of nervous tissue donors. We investigated the potential of Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) in differentiating into Schwann cell-like cells (WJ-SCLCs) as an alternative to SCs. We also examined whether implantation of WJ-SCLCs-laden acellular nerve grafts (ANGs) are effective in inducing functional recovery and nerve regeneration in an animal model of peripheral nerve injury.