Open AccessGeneration of Hepatic Progenitor Cells from the Primary Hepatocytes of Nonhuman Primates Using Small Molecules
Author(s) -
Da Hee Hong,
Changhee Lee,
Young S. Kim,
Seung Bum Lee,
Sang-Seop Han,
Sung Joo Kim,
Heung Mo Yang,
Dongho Choi,
Jaemin Jeong,
Ki Young Ryu
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00327-8
Subject(s) - progenitor cell , reprogramming , regenerative medicine , hepatocyte , biology , hepatocyte growth factor , microbiology and biotechnology , progenitor , stem cell , cholangiocyte , liver cytology , cellular differentiation , in vitro , immunology , cell , biochemistry , endocrinology , liver metabolism , receptor , gene
Since primates have more biological similarities to humans than do other animals, they are a valuable resource in various field of research, including biomedicine, regenerative medicine, and drug discovery. However, there remain limitations to maintenance and expansion of primary hepatocytes derived from nonhuman primates. To overcome these limitations, we developed a novel culture system for primate cells.