Open AccessThe Therapeutic Potential of Amniotic Fluid-Derived Stem Cells on Busulfan-Induced Azoospermia in Adult Rats
Author(s) -
Heba Ibrahim,
Safinaz Hussein Safwat,
Teshreen M. Zeitoun,
K. F. El Mulla,
Amira Y Medwar
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00309-w
Subject(s) - azoospermia , stem cell , busulfan , andrology , male infertility , pathology , medicine , biology , infertility , microbiology and biotechnology , hematopoietic stem cell transplantation , pregnancy , genetics
Busulfan is an alkylating chemotherapeutic agent that is routinely prescribed for leukemic patients to induce myelo-ablation. However, it also results in azoospermia and infertility in cancer survivors. This research was constructed to explore the possible therapeutic role of amniotic fluid-derived stem cells (AFSCs) in improving busulfan-induced azoospermia in adult rats.