Open AccessNitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process
Author(s) -
Yu Na Han,
Yoon Jae Lee,
Ki Joo Kim,
Su Jin Lee,
Jang Youn Choi,
SukHo Moon,
Jong Won Rhie
Publication year - 2021
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00308-x
Subject(s) - wound healing , verapamil , pharmacology , angiogenesis , nitric oxide synthase , chemistry , medicine , nitric oxide , surgery , calcium
Verapamil is used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, hypertrophic scars, and keloids to block transmembrane calcium ion flux. Verapamil has antioxidant activity, which enhances the production of nitric oxide (NO). NO promotes the proliferation of fibroblasts, keratinocytes, endothelial cells, and epithelial cells during wound healing. In this study, we investigated the effect of verapamil and its antioxidant properties on the enhancement of acute wound healing via NO.