Open AccessMannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model
Author(s) -
Sang Hoon Lee,
Ho Young Kang,
Jong Hoon Kim,
Dong Hyuk Park
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00293-1
Subject(s) - transplantation , subventricular zone , mannitol , stem cell , doublecortin , neural stem cell , medicine , neuroprotection , pharmacology , biology , dentate gyrus , hippocampus , microbiology and biotechnology , biochemistry
Mannitol increases blood-brain barrier permeability and can improve the efficiency of systemically administered stem cells by facilitating stem cell entry from the periphery into the injured brain. The aim of this study was to elucidate the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury.