Open AccessElectrospun Microvasculature for Rapid Vascular Network Restoration
Author(s) -
Je-Hyun Han,
Ung Hyun Ko,
Hyo Jun Kim,
Seung Gyu Kim,
Jessie S. Jeon,
Jennifer Hyunjong Shin
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00292-2
Subject(s) - scaffold , angiogenesis , tissue engineering , biomedical engineering , regenerative medicine , regeneration (biology) , in vivo , electrospinning , materials science , stem cell , nanotechnology , microbiology and biotechnology , medicine , biology , cancer research , composite material , polymer
Sufficient blood supply through neo-vasculature is a major challenge in cell therapy and tissue engineering in order to support the growth, function, and viability of implanted cells. However, depending on the implant size and cell types, the natural process of angiogenesis may not provide enough blood supply for long term survival of the implants, requiring supplementary strategy to prevent local ischemia. Many researchers have reported the methodologies to form pre-vasculatures that mimic in vivo microvessels for implantation to promote angiogenesis. These approaches successfully showed significant enhancement in long-term survival and regenerative functions of implanted cells, yet there remains room for improvement.