Open AccessBone Generation Following Repeated Administration of Recombinant Bone Morphogenetic Protein 2
Author(s) -
Hye-Ju Son,
Mi Nam Lee,
Yuri Kim,
Hyung-Seok Choi,
ByungChul Jeong,
So-Young Oh,
Jung-Woo Kim,
Seung-Hee Kwon,
Sun-Hun Kim,
SooChang Song,
Shee Eun Lee,
JeongTae Koh
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00290-4
Subject(s) - bone morphogenetic protein 2 , bone morphogenetic protein , medicine , route of administration , in vivo , recombinant dna , pharmacology , chemistry , in vitro , biology , biochemistry , microbiology and biotechnology , gene
The delivery of recombinant human bone morphogenetic protein 2 (rhBMP2) by using various carriers has been used to successfully induce bone formation in many animal models. However, the effect of multiple administration of rhBMP2 on bone formation and BMP2 antibody production has not been determined. Our aim was to examine the bone formation activity of rhBMP2 and serum levels of anti-BMP2 antibodies following the repeated administration of rhBMP2 in mice.