Open AccessChallenges in Perioperative Animal Care for Orthotopic Implantation of Tissue-Engineered Pulmonary Valves in the Ovine Model
Author(s) -
Hussam Al Hussein,
Hamida Al Hussein,
Carmen Sircuța,
Ovidiu Simion Cotoi,
Ionela Movileanu,
Dan Nistor,
Bogdan Cordoş,
Radu Deac,
Horațiu Suciu,
Klara Brînzaniuc,
Dan T. Simionescu,
Marius Harpa
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00285-1
Subject(s) - medicine , perioperative , anesthetic , surgery , sedation , cardiopulmonary bypass , anesthesia , intensive care medicine
Development of valvular substitutes meeting the performance criteria for surgical correction of congenital heart malformations is a major research challenge. The sheep is probably the most widely used animal model in heart valves regenerative medicine. Although the standard cardiopulmonary bypass (CPB) technique and various anesthetic and surgical protocols are reported to be feasible and safe, they are associated with significant morbidity and mortality rates. The premise of this paper is that the surgical technique itself, especially the perioperative animal care and management protocol, is essential for successful outcomes and survival.