Open AccessEffect of Integrin Binding Peptide on Vascularization of Scaffold-Free Microtissue Spheroids
Author(s) -
Ziyşan Buse Yaralı,
Günnur Onak,
Ozan Karaman
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00281-5
Subject(s) - spheroid , extracellular matrix , tissue engineering , umbilical vein , scaffold , chemistry , integrin , microbiology and biotechnology , viability assay , peptide , cell adhesion , biomedical engineering , cell , in vitro , biophysics , biochemistry , biology , medicine
Three-dimensional (3D) biomimetic models via various approaches can be used by therapeutic applications of tissue engineering. Creating an optimal vascular microenvironment in 3D model that mimics the extracellular matrix (ECM) and providing an adequate blood supply for the survival of cell transplants are major challenge that need to be overcome in tissue regeneration. However, currently available scaffolds-depended approaches fail to mimic essential functions of natural ECM. Scaffold-free microtissues (SFMs) can successfully overcome some of the major challenges caused by scaffold biomaterials such as low cell viability and high cost.