Open AccessEvaluation of Intestinal Epithelial Barrier Function in Inflammatory Bowel Diseases Using Murine Intestinal Organoids
Author(s) -
Harikrishna Reddy Rallabandi,
Hyeon Yang,
Keon Bong Oh,
Hwi Cheul Lee,
Sung June Byun,
Bo Ram Lee
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00278-0
Subject(s) - paracellular transport , organoid , barrier function , intestinal epithelium , intestinal permeability , inflammatory bowel disease , proinflammatory cytokine , intestinal mucosa , microbiology and biotechnology , in vivo , chemistry , biology , epithelium , immunology , inflammation , medicine , permeability (electromagnetism) , pathology , biochemistry , disease , genetics , membrane
Intestinal organoids have evolved as potential molecular tools that could be used to study host-microbiome interactions, nutrient uptake, and drug screening. Gut epithelial barrier functions play a crucial role in health and diseases, especially in autoimmune diseases, such as inflammatory bowel diseases (IBDs), because they disrupt the epithelial mucosa and impair barrier function.