Open AccessCirc_0068655 Promotes Cardiomyocyte Apoptosis via miR-498/PAWR Axis
Author(s) -
Qiaoying Chai,
Mingqi Zheng,
Le Wang,
Wei Mei,
Yajuan Yin,
Fangfang Ma,
Xinping Li,
Haijun Zhang,
Gang Li
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00270-8
Subject(s) - gene knockdown , apoptosis , western blot , microrna , hypoxia (environmental) , programmed cell death , luciferase , viability assay , regulator , microbiology and biotechnology , endogeny , biology , cell growth , chemistry , cell culture , transfection , endocrinology , gene , biochemistry , genetics , organic chemistry , oxygen
The cardiomyocyte apoptosis is considered as one of major contributions to cardiac remodeling after myocardial infarction (MI). Numerous studies find that circular RNAs (circRNAs) play pivotal roles in a variety of biological functions. However, the role of circ_0068655 in MI and human induced pluripotent stem-derived cardiomyocytes (HCMs) remains unknown.