Open AccessDevelopment of Acellular Respiratory Mucosal Matrix Using Porcine Tracheal Mucosa
Author(s) -
Soo Yeon Jung,
An Nguyen Thuy Tran,
Ha Yeong Kim,
Eun Hye Choi,
So Jeong Lee
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00260-w
Subject(s) - decellularization , respiratory mucosa , extracellular matrix , tissue engineering , cartilage , pathology , transplantation , glycosaminoglycan , chemistry , wound healing , epithelium , anatomy , microbiology and biotechnology , medicine , biomedical engineering , biology , immunology , surgery
Respiratory mucosa defects result in airway obstruction and infection, requiring subsequent functional recovery of the respiratory epithelium. Because site-specific extracellular matrix (ECM) facilitates restoration of organ function by promoting cellular migration and engraftment, previous studies considered decellularized trachea an ideal ECM; however, incomplete cell removal from cartilage and mucosal-architecture destruction are frequently reported. Here, we developed a decellularization protocol and applied it to the respiratory mucosa of separated porcine tracheas.