Open AccessOsteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting
Author(s) -
Nadia S. Mahmoud,
Mohamed R. Mohamed,
Mohamed A. Ali,
Hadeer A. Aglan,
Khalda Amr,
Hanaa H. Ahmed
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00249-5
Subject(s) - rankl , osteoprotegerin , medicine , sclerostin , endocrinology , bone remodeling , ovariectomized rat , osteoporosis , bone sialoprotein , cathepsin k , chemistry , osteoblast , transplantation , alkaline phosphatase , osteocalcin , osteoclast , wnt signaling pathway , activator (genetics) , receptor , signal transduction , estrogen , biochemistry , in vitro , enzyme
Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation, generated upon culturing male rat bone marrow-derived mesenchymal stem cells (BM-MSCs) in osteogenic medium (OM), OM containing gold (Au-NPs) or gold/hydroxyapatite (Au/HA-NPs) nanoparticles, in ovariectomized rats to counteract osteoporosis.