Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting | Zendy

Nadia S. Mahmoud | Zendy; Mohamed R. Mohamed | Zendy; Mohamed A. M. Ali | Zendy; Hadeer A. Aglan | Zendy; Khalda Amr | Zendy; Hanaa H. Ahmed | Zendy

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Osteoblast-Based Therapy—A New Approach for Bone Repair in Osteoporosis: Pre-Clinical Setting

Author(s) -

Nadia S. Mahmoud,

Mohamed R. Mohamed,

Mohamed A. M. Ali,

Hadeer A. Aglan,

Khalda Amr,

Hanaa H. Ahmed

Publication year - 2020

Publication title -

tissue engineering and regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.719

H-Index - 23

eISSN - 2212-5469

pISSN - 1738-2696

DOI - 10.1007/s13770-020-00249-5

Subject(s) - osteoprotegerin , rankl , sclerostin , medicine , endocrinology , bone remodeling , ovariectomized rat , osteoporosis , bone sialoprotein , cathepsin k , chemistry , osteoblast , transplantation , alkaline phosphatase , osteocalcin , osteoclast , wnt signaling pathway , activator (genetics) , receptor , signal transduction , estrogen , in vitro , biochemistry , enzyme

Osteoporosis is a metabolic bone disease characterized by low bone density resulting in increased fracture susceptibility. This research was constructed to uncover the potential therapeutic application of osteoblasts transplantation, generated upon culturing male rat bone marrow-derived mesenchymal stem cells (BM-MSCs) in osteogenic medium (OM), OM containing gold (Au-NPs) or gold/hydroxyapatite (Au/HA-NPs) nanoparticles, in ovariectomized rats to counteract osteoporosis.

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