Open AccessGaining New Biological and Therapeutic Applications into the Liver with 3D In Vitro Liver Models
Author(s) -
Sang Woo Lee,
Da-Jung Jung,
Gi Seok Jeong
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00245-9
Subject(s) - scaffold , tissue engineering , organoid , 3d cell culture , liver tissue , function (biology) , computer science , computational biology , in vitro , biology , microbiology and biotechnology , biomedical engineering , medicine , biochemistry , endocrinology
Three-dimensional (3D) cell cultures with architectural and biomechanical properties similar to those of natural tissue have been the focus for generating liver tissue. Microarchitectural organization is believed to be crucial to hepatic function, and 3D cell culture technologies have enabled the construction of tissue-like microenvironments, thereby leading to remarkable progress in vitro models of human tissue and organs. Recently, to recapitulate the 3D architecture of tissues, spheroids and organoids have become widely accepted as new practical tools for 3D organ modeling. Moreover, the combination of bioengineering approach offers the promise to more accurately model the tissue microenvironment of human organs. Indeed, the employment of sophisticated bioengineered liver models show long-term viability and functional enhancements in biochemical parameters and disease-orient outcome.