Open AccessAdaptation of Human Testicular Niche Cells for Pluripotent Stem Cell and Testis Development Research
Author(s) -
Marina V. Pryzhkova,
Philip W. Jordan
Publication year - 2020
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-020-00240-0
Subject(s) - biology , induced pluripotent stem cell , somatic cell , microbiology and biotechnology , sertoli cell , cell type , stem cell , transgene , cell , immunology , embryonic stem cell , spermatogenesis , endocrinology , genetics , gene
Human testicular cells are greatly valuable to the research community as tools for studying testicular physiology and the effects of environmental pollutants. Because adult testicular cells have a limited self-organization capacity and life span, we investigated whether human pluripotent stem cells (hPSCs) can be used together with testicular cells to move a step closer toward making an optimal model of the human testis.