Open AccessCombined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions
Author(s) -
Yeomin Yun,
Daye Baek,
Dongsu Lee,
Eunji Cheong,
Janghwan Kim,
Jinsoo Oh,
Yoon Ha
Publication year - 2019
Publication title -
tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-019-00223-w
Subject(s) - valproic acid , enolase , gene expression , neural stem cell , microbiology and biotechnology , genetic enhancement , biology , stem cell , in vivo , cancer research , chemistry , gene , biochemistry , immunology , immunohistochemistry , epilepsy , neuroscience
Gene therapy shows the ability to restore neuronal dysfunction via therapeutic gene expression. The efficiency of gene expression and delivery to hypoxic injury sites is important for successful gene therapy. Therefore, we established a gene/stem cell therapy system using neuron-specific enolase promoter and induced neural stem cells in combination with valproic acid to increase therapeutic gene expression in hypoxic spinal cord injury.
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