Open AccessCombined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions
Author(s) -
Young Yun,
Daye Baek,
Dongsu Lee,
Eunji Cheong,
Jang Hwan Kim,
Jaehak Oh
Publication year - 2019
Publication title -
jo'jig gonghag gwa jaesaeng uihag/tissue engineering and regenerative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 23
eISSN - 2212-5469
pISSN - 1738-2696
DOI - 10.1007/s13770-019-00223-w
Subject(s) - valproic acid , gene expression , enolase , neural stem cell , genetic enhancement , microbiology and biotechnology , stem cell , biology , in vivo , embryonic stem cell , cancer research , chemistry , gene , biochemistry , immunology , immunohistochemistry , epilepsy , neuroscience , genetics
Gene therapy shows the ability to restore neuronal dysfunction via therapeutic gene expression. The efficiency of gene expression and delivery to hypoxic injury sites is important for successful gene therapy. Therefore, we established a gene/stem cell therapy system using neuron-specific enolase promoter and induced neural stem cells in combination with valproic acid to increase therapeutic gene expression in hypoxic spinal cord injury.