Open AccessA case of minimal change nephrotic syndrome with pregnancy
Author(s) -
Mari Horigome,
Ryu Kobayashi,
Masaaki Hanaoka,
Sho Kinguchi,
Tomohiko Kanaoka,
Yoshiyuki Toya,
Hiromichi Wakui,
Kouichi Tamura
Publication year - 2021
Publication title -
cen case reports
Language(s) - English
Resource type - Journals
ISSN - 2192-4449
DOI - 10.1007/s13730-020-00568-5
Subject(s) - medicine , nephrotic syndrome , hypoalbuminemia , prednisolone , proteinuria , concomitant , oliguria , gestation , methylprednisolone , pregnancy , nephrology , renal biopsy , gastroenterology , surgery , biopsy , kidney , renal function , biology , genetics
A 32-year-old Japanese woman at 8 weeks of gestation was admitted to our hospital for systemic edema, hypoalbuminemia, and severe proteinuria. The patient had a history of generalized alopecia and migraine. We diagnosed nephrotic syndrome, and renal biopsy revealed minimal change nephrotic syndrome (MCNS). We administered 1000 mg/day of methylprednisolone for 3 days. Oral corticosteroid therapy was followed by 40 mg of prednisolone daily. We carefully selected concomitant medication after considering organogenesis. Before and after renal biopsy, we administered heparin, antithrombin III, and immunoglobulin agents as appropriate. The patient achieved complete remission on day 8 of treatment and gave birth to a boy at 37 weeks of gestation without recurrence. MCNS during pregnancy is rare, and there is no established treatment. In conclusion, we present a case of a pregnant woman with MCNS during organogenesis. Early treatment initiation can provide a good prognosis for both mother and child.