Open AccessThree New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
Author(s) -
Xin Wei,
Afsar Khan,
Da Song,
Zhi Dai,
Yaping Liu,
Hua Yu,
Bei Wang,
Peifen Zhu,
CaiFeng Ding,
Xudong Zhao,
Yifen Wang,
XiaoDong Luo
Publication year - 2017
Publication title -
natural products and bioprospecting
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 21
eISSN - 2192-2195
pISSN - 2192-2209
DOI - 10.1007/s13659-017-0137-7
Subject(s) - vinca , plant biochemistry , natural product research , biopharmaceutics , traditional medicine , biology , medicine , botany , pharmacognosy , biochemistry , in vitro , gene , biological activity
Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3 # and GITC-18 # ), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.