Open AccessEstablishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma
Author(s) -
Jhudit Pérez-Escuredo,
Jorge García Martínez,
Cristina GarcíaInclán,
Blanca Vivanco,
María Costales,
César Marcos,
José Luís Llorente,
Mario Hermsen
Publication year - 2011
Publication title -
cellular oncology
Language(s) - English
Resource type - Journals
eISSN - 2211-3436
pISSN - 2211-3428
DOI - 10.1007/s13402-010-0002-8
Subject(s) - biology , comparative genomic hybridization , cancer research , mutation , cell culture , genetics , gene , chromosome
Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor etiologically related to professional exposure to wood dust. The overall prognosis is poor, mainly due to the difficulty to resect the tumor completely in this anatomically complex region. Therefore, there is great need for alternative treatments. However, the lack of a good tumor model system for ITAC has hampered the development and testing of new therapeutic agents. Here, we report the establishment and characterization of the first human ITAC cell line named ITAC-3.