Establishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma | Zendy

Jhudit PérezEscuredo | Zendy; Jorge García Martínez | Zendy; Cristina García–Inclán | Zendy; Blanca Vivanco | Zendy; María Costales | Zendy; César Álvarez Marcos | Zendy; José Luís Llorente | Zendy; Mario Hermsen | Zendy

Open Access

Establishment and genetic characterization of an immortal tumor cell line derived from intestinal-type sinonasal adenocarcinoma

Author(s) -

Jhudit PérezEscuredo,

Jorge García Martínez,

Cristina García–Inclán,

Blanca Vivanco,

María Costales,

César Álvarez Marcos,

José Luís Llorente,

Mario Hermsen

Publication year - 2011

Publication title -

cellular oncology

Language(s) - English

Resource type - Journals

eISSN - 2211-3436

pISSN - 2211-3428

DOI - 10.1007/s13402-010-0002-8

Subject(s) - biology , comparative genomic hybridization , cancer research , mutation , cell culture , genetics , gene , chromosome

Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumor etiologically related to professional exposure to wood dust. The overall prognosis is poor, mainly due to the difficulty to resect the tumor completely in this anatomically complex region. Therefore, there is great need for alternative treatments. However, the lack of a good tumor model system for ITAC has hampered the development and testing of new therapeutic agents. Here, we report the establishment and characterization of the first human ITAC cell line named ITAC-3.

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