Open AccessDownregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells
Author(s) -
Jin Ku Kang,
Chang-Hyun Chang,
Hyo Jung Nam,
Sungkuk Kim,
Keun Jae Ahn,
Heon Seok,
Sang Joon Park,
YoonSuk Kang,
Young Suk Jo,
Minho Shong,
Ho Kim
Publication year - 2011
Publication title -
cellular oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.698
H-Index - 40
eISSN - 2211-3436
pISSN - 2211-3428
DOI - 10.1007/s13402-010-0001-9
Subject(s) - downregulation and upregulation , erythropoietin , focal adhesion , receptor , adhesion , microbiology and biotechnology , phospholipase , cancer research , phospholipase c , phospholipase d , chemistry , signal transduction , medicine , biology , enzyme , biochemistry , gene , organic chemistry
Phospholipase C-γl (PLC-γl) is known to play a critical role in cell adhesion and migration and is highly expressed in metastatic tumors. In the current study, we found that cells transformed by PLC overexpression (PLC-γl cells) exhibited a marked decrease in expression of the Epo receptor (EpoR). Here, we assessed the role of EpoR-dependent signaling pathways in PLC-γl-dependent regulation of cell adhesion and migration.