Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells | Zendy

Jin Ku Kang | Zendy; Chang-Hyun Chang | Zendy; Hyo Jung Nam | Zendy; Sung-Kuk Kim | Zendy; Keun Jae Ahn | Zendy; Heon Seok | Zendy; Sang Joon Park | Zendy; Yoon Joong Kang | Zendy; Young Suk Jo | Zendy; Minho Shong | Zendy; Ho Kim | Zendy

Open Access

Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells

Author(s) -

Jin Ku Kang,

Chang-Hyun Chang,

Hyo Jung Nam,

Sung-Kuk Kim,

Keun Jae Ahn,

Heon Seok,

Sang Joon Park,

Yoon Joong Kang,

Young Suk Jo,

Minho Shong,

Ho Kim

Publication year - 2011

Publication title -

cellular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.698

H-Index - 40

eISSN - 2211-3436

pISSN - 2211-3428

DOI - 10.1007/s13402-010-0001-9

Subject(s) - downregulation and upregulation , erythropoietin , focal adhesion , receptor , adhesion , microbiology and biotechnology , phospholipase , cancer research , phospholipase c , phospholipase d , chemistry , signal transduction , medicine , biology , enzyme , biochemistry , gene , organic chemistry

Phospholipase C-γl (PLC-γl) is known to play a critical role in cell adhesion and migration and is highly expressed in metastatic tumors. In the current study, we found that cells transformed by PLC overexpression (PLC-γl cells) exhibited a marked decrease in expression of the Epo receptor (EpoR). Here, we assessed the role of EpoR-dependent signaling pathways in PLC-γl-dependent regulation of cell adhesion and migration.

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