Open AccessProgressive multifocal leukoencephalopathy in an HIV patient was diagnosed by 3 times lumbar punctures and 2 times brain biopsies
Author(s) -
Mengyan Wang,
Zhongdong Zhang,
Jinchuan Shi,
Hong Liu,
Binhai Zhang,
Jinhui Yan
Publication year - 2020
Publication title -
journal of neurovirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.868
H-Index - 85
eISSN - 1538-2443
pISSN - 1355-0284
DOI - 10.1007/s13365-020-00893-6
Subject(s) - progressive multifocal leukoencephalopathy , medicine , human immunodeficiency virus (hiv) , neurology , lumbar , leukoencephalopathy , lumbar puncture , pediatrics , pathology , radiology , virology , psychiatry , cerebrospinal fluid , virus , disease
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by JC virus (JCV) and is difficult to diagnose. We report on a male HIV-positive patient with PML finally diagnosed by 3 times lumbar punctures and 2 times brain biopsies. Negative results of JCV-PCR in cerebrospinal fluid (CSF) do not rule out the diagnosis of PML when clinical manifestations and neuroimaging features suspected PML. It is necessary to obtain new CSF and make repeat tests and even perform brain biopsy.