Open AccessBasal insulin ameliorates post-breakfast hyperglycemia via suppression of post-breakfast proinsulin/C-peptide ratio and fasting serum free fatty acid levels in patients with type 2 diabetes
Author(s) -
Kazuma Ogiso,
Nobuyuki Koriyama,
Takahiko Obo,
Akinori Tokito,
Yoshihiko Nishio
Publication year - 2020
Publication title -
diabetology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.411
H-Index - 17
eISSN - 2190-1686
pISSN - 2190-1678
DOI - 10.1007/s13340-020-00457-3
Subject(s) - medicine , insulin glargine , postprandial , endocrinology , insulin , type 2 diabetes , basal (medicine) , c peptide , diabetes mellitus , proinsulin , meal , basal insulin
In general, basal insulin targets fasting plasma glucose (FPG) levels, and prandial insulin targets postprandial glucose (PPG) levels. However, the effects of basal insulin on PPG levels are controversial. We investigated the effect of basal insulin on postprandial hyperglycemia using a test meal at breakfast as well as compared differences between degludec and glargine.