Open AccessEvaluation of the Effect of Crosslinking Method of Poly(Vinyl Alcohol) Hydrogels on Thrombogenicity
Author(s) -
Novella M Bates,
Cristina Puy,
Patrick Jurney,
Owen J. T. McCarty,
Monica T. Hinds
Publication year - 2020
Publication title -
cardiovascular engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 25
eISSN - 1869-4098
pISSN - 1869-408X
DOI - 10.1007/s13239-020-00474-y
Subject(s) - thrombogenicity , vinyl alcohol , self healing hydrogels , biomaterial , materials science , adhesion , platelet activation , glutaraldehyde , fibrin , polymer chemistry , chemical engineering , chemistry , platelet , composite material , nanotechnology , polymer , organic chemistry , engineering , immunology , biology
Crosslinked poly(vinyl alcohol) (PVA) is a biomaterial that can be used for multiple cardiovascular applications. The success of implanted biomaterials is contingent on the properties of the material. A crucial consideration for blood-contacting devices is their potential to incite thrombus formation, which is dependent on the material surface properties. The goal of this study was to quantify the effect of different crosslinking methods of PVA hydrogels on in vitro thrombogenicity.