Open AccessLarge-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis
Author(s) -
Nicolas Tobin,
Keefe B. Manning
Publication year - 2020
Publication title -
cardiovascular engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 25
eISSN - 1869-4098
pISSN - 1869-408X
DOI - 10.1007/s13239-020-00461-3
Subject(s) - turbulence , laminar flow , intermittency , mechanics , hemolysis , large eddy simulation , computational fluid dynamics , statistical physics , physics , medicine , immunology
Modeling of hemolysis due to fluid stresses faces significant methodological challenges, particularly in geometries with turbulence or complex flow patterns. It is currently unclear how existing phenomenological blood-damage models based on laminar viscous stresses can be implemented into turbulent computational fluid dynamics simulations. The aim of this work is to generalize the existing laminar models to turbulent flows based on first principles, and validate this generalization with existing experimental data.