Open AccessMethylenetetrahydrofolate Reductase Enzyme Level and Antioxidant Activity in Women with Gestational Hypertension and Pre-eclampsia in Lagos, Nigeria
Author(s) -
Vincent Oluseye Osunkalu,
I.A. Taiwo,
Christian Chigozie Makwe,
O J Akinsola,
R. A. Quao
Publication year - 2019
Publication title -
journal of obstetrics and gynecology of india
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.313
H-Index - 17
eISSN - 0971-9202
pISSN - 0975-6434
DOI - 10.1007/s13224-019-01215-5
Subject(s) - methylenetetrahydrofolate reductase , homocysteine , lipid peroxidation , malondialdehyde , medicine , oxidative stress , endocrinology , eclampsia , gestational hypertension , glutathione reductase , superoxide dismutase , antioxidant , glutathione peroxidase , preeclampsia , pregnancy , biochemistry , chemistry , biology , genetics , genotype , gene
Deficiencies of enzymes in the folate cycle may lead to the generation of homocysteine, a toxic metabolic intermediate with pro-oxidant effect and ability to induce oxidant stress and lipid peroxidation as part of the pathophysiological process in gestational hypertension (GH) and pre-eclampsia (PE).