Open AccessEffects of soy protein isolate hydrolysates on cholecystokinin released by rat intestinal mucosal cells and food intake in rats
Author(s) -
Yang Yang,
Qingbin Guo,
Huanan Guan,
Wojciech Piekoszewski,
Bing Wang,
Linlin Liu,
Yùzhēn Shí,
Shinya Ikeda,
Lijie Liu,
Tatiyana Kalenik,
Na Zhang
Publication year - 2020
Publication title -
journal of food science and technology/journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.656
H-Index - 68
eISSN - 0975-8402
pISSN - 0022-1155
DOI - 10.1007/s13197-020-04483-6
Subject(s) - cholecystokinin , soy protein , hydrolysate , meal , chemistry , food science , dietary fiber , food intake , endocrinology , medicine , biology , biochemistry , receptor , hydrolysis
Soy protein isolate hydrolysates (SPIH) were prepared from soy protein isolate (SPI). Effects of SPIH on a satiety signal cholecystokinin (CCK) and feeding behavior in rats were investigated. SPIH induced more CCK release (164.66 ± 2.40 pg/mL) by rat intestinal mucosal cells than SPI (143.33 ± 3.71 pg/mL). Meal size (MS), intermeal interval (IMI), and satiety ratio (SR = MS/IMI) of rats received different daily doses of SPIH or dietary fiber were detected for 40 days. A 100 mg/kg dose of SPIH resulted in a greater SR than an identical dose of dietary fiber, while a 300 mg/kg dose resulted in a less MS and IMI. A 500 mg/kg dose of SPIH had similar effects to the same dose of dietary fiber on reducing MS, extending IMI, and increasing SR, but resulted in a significantly less body weight at the end of the experiment (318.15 ± 17.83 g) than the dietary fiber group (340.28 ± 6.15 g).