Open AccessAberrant Promoter Hypermethylation of p16 and RASSF1a Genes in Colorectal Cancer – Significance in Young Patients
Author(s) -
Medha Sugara,
C. Ramachandra,
K.V. Veerendra Kumar,
Gayathri Ramesh,
Shalini N Swamy,
Sandeep Kumar
Publication year - 2021
Publication title -
indian journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 16
eISSN - 0976-6952
pISSN - 0975-7651
DOI - 10.1007/s13193-021-01325-5
Subject(s) - colorectal cancer , microsatellite instability , dna methylation , surgical oncology , epigenetics , medicine , methylation , cancer , oncology , cancer research , population , gene , biology , microsatellite , genetics , gene expression , allele , environmental health
The clinical profile of colorectal cancers (CRC) in India is different from that described in western countries. Microsatellite instability and APC mutation explain the molecular biology of up to 50% of colorectal cancers. Global genome hypermethylation may be the cause in at least 20% of cases. Few studies from India have examined the epigenetic profile of colorectal cancers. This study was designed to study aberrant promoter hypermethylation of two select tumour suppressor genes ( p16, RASSF1a ) in patients with colorectal cancer and their association with clinicopathologic features.