Open AccessMolecular Signatures of Gynecological Cancers: Clinicians Perspective
Author(s) -
TS Shylasree,
Bansal Richa,
Lavanya Gurram,
Seema Gulia
Publication year - 2021
Publication title -
indian journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.231
H-Index - 16
eISSN - 0976-6952
pISSN - 0975-7651
DOI - 10.1007/s13193-020-01271-8
Subject(s) - surgical oncology , medicine , precision medicine , dna sequencing , personalized medicine , profiling (computer programming) , precision oncology , oncology , bioinformatics , computational biology , gene , pathology , biology , genetics , computer science , operating system
Large-scale molecular profiling and DNA sequencing has revolutionized cancer research. Precision medicine is a rapidly developing area in cancer care but it is not uniformly applied across different tumor types. Biomarker-based therapy is associated with improved outcomes, both in terms of progression-free survival and overall survival. Comprehensive genomic profiling (CGP) uses next-generation sequencing to analyze the complete coding sequence of hundreds of genes from a small amount of tissue. Genes included in these assays are those associated with cancer development or have diagnostic, prognostic, familial, or therapeutic implications Genomic profiling is emerging as a clinically viable tool to personalize patient's treatment. This article discusses how the insights gained through CGP can impact treatment plan in common gynecological cancers.