Open AccessA Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis
Author(s) -
Stephen A. Harding,
Rana Biary,
Robert S. Hoffman,
Mark K. Su,
Mary Ann Howland
Publication year - 2020
Publication title -
journal of medical toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 49
eISSN - 1937-6995
pISSN - 1556-9039
DOI - 10.1007/s13181-020-00802-7
Subject(s) - medicine , metformin , hemodialysis , metabolic acidosis , lactic acidosis , acute kidney injury , urine , acidosis , creatinine , diabetes mellitus , gastroenterology , urology , endocrinology
Although hemodialysis is recommended for patients with severe metformin-associated lactic acidosis (MALA), the amount of metformin removed by hemodialysis is poorly documented. We analyzed endogenous clearance and hemodialysis clearance in a patient with MALA.