Open AccessAntidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events
Author(s) -
Siri Shastry,
Judson Ellis,
George Loo,
Rajesh Vedanthan,
Lynne D. Richardson,
Alex F. Manini
Publication year - 2020
Publication title -
journal of medical toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 49
eISSN - 1937-6995
pISSN - 1556-9039
DOI - 10.1007/s13181-020-00799-z
Subject(s) - medicine , qt interval , sodium bicarbonate , cohort , adverse effect , bolus (digestion) , retrospective cohort study , emergency department , acidosis , propensity score matching , anesthesia , drug overdose , emergency medicine , poison control , chemistry , psychiatry
Sodium bicarbonate therapy (SBT) is currently indicated for the management of a variety of acute drug poisonings. However, SBT effects on serum potassium concentrations may lead to delayed QTc prolongation (DQTP), and subsequent risk of adverse cardiovascular events (ACVE), including death. Emergency department (ED)-based studies evaluating associations between SBT and ACVE are limited; thus, we aimed to investigate the association between antidotal SBT, ECG changes, and ACVE.