Open AccessAdducts Post Acetaminophen Overdose Treated with a 12-Hour vs 20-Hour Acetylcysteine Infusion
Author(s) -
Anselm Wong,
Ken Heard,
Andis Graudins,
Richard C. Dart,
Marco L.A. Sivilotti
Publication year - 2020
Publication title -
journal of medical toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.534
H-Index - 49
eISSN - 1937-6995
pISSN - 1556-9039
DOI - 10.1007/s13181-020-00757-9
Subject(s) - acetylcysteine , acetaminophen , medicine , regimen , acetaminophen overdose , alanine transaminase , antidote , adduct , gastroenterology , anesthesia , toxicity , chemistry , biochemistry , organic chemistry , antioxidant
Acetaminophen protein adducts in the circulation are a specific biomarker of acetaminophen oxidation, and may be a more sensitive measure of impending hepatic injury following overdose than alanine transaminase (ALT). We performed an exploratory analytical substudy of adducts during a clinical trial (NACSTOP) of abbreviated (12-hour) versus control (20-hour) acetylcysteine to identify any signal of diminished antidotal effectiveness with shortened therapy.