Open AccessHuman growth hormone proteoform pattern changes in pituitary adenomas: Potential biomarkers for 3P medical approaches
Author(s) -
Biao Li,
Xiaowei Wang,
Chenguang Yang,
Siqi Wen,
Jiajia Li,
Na Li,
Ying Long,
Yun Mu,
Jianping Liu,
Liu Q,
Xuejun Li,
Dominic M. Desiderio,
Xianquan Zhan
Publication year - 2021
Publication title -
the epma journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.177
H-Index - 34
eISSN - 1878-5085
pISSN - 1878-5077
DOI - 10.1007/s13167-021-00232-7
Subject(s) - somatotropic cell , pituitary adenoma , medicine , endocrinology , pituitary gland , adenoma , biology , hormone
Human growth hormone (hGH) is synthesized, stored, and secreted by somatotroph cells in the pituitary gland, and promotes human growth and metabolism. Compared to a normal pituitary, a GH-secreting pituitary adenoma can secrete excessive GH to cause pathological changes in body tissues. GH proteoform changes would be associated with GH-related disease pathogenesis.